Proprotein convertase subtilisin/kexin type 9 (PCSK9), LDLR-binding epitope blocking
This anitbody is made to an epitope that is reported to block the PCSK9-LDLR (low density lipoprotein receptor) interaction. PCSK9 binds to the EGF-A domain of the LDLR and signals LDLR degradation. Reduced LDLR levels result in decreased LDL (low density lipid) metabolism leading to hypercholesterolemia. Additioanlly, PCSK9 may be implicated in the differentiation of cortical neurons and may also play a role in cholesterol homeostasis. Defects in PCSK9 gene are the cause of familial hypercholesterolemia 3 (FH3). The protein is thought to play a central role in cholesterol homeostais
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Proprotein convertase subtilisin/kexin type 9 (PCSK9), LDLR-binding epitope blocking
X2404P
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Proprotein convertase subtilisin/kexin type 9 (PCSK9), LDLR-binding epitope blocking
X2404P
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