SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody
Solute carrier family 3 member 2 (SLC3A2), also known as CD98 heavy chain (CD98hc), is a type II transmembrane glycoprotein.{49766,49768,49767,49769} It is expressed in all cell types except platelets, with the highest levels in the gastrointestinal tract and renal tubules.{49768} SLC3A2 is composed of an extracellular domain, a single-pass transmembrane region, and a cytoplasmic domain. It heterodimerizes with various light chains, including the large neutral amino acids transporter small subunit 1 (LAT1) and LAT2, to form sodium-dependent transporters for neutral and positively charged amino acids and associates with ? integrins to regulate integrin affinity and signaling, resulting in alterations in cell proliferation, adhesion, migration, and differentiation.{49766} SLC3A2 is associated with tumor growth, aggressiveness, and poor prognosis in patients with biliary tract cancer.{49770} It is also expressed on low-density neutrophils (LDNs), a subset of the neutrophil population that expands in patients with autoimmune disease, and is positively correlated with disease severity in patients with systemic lupus erythematosus (SLE).{49771} Cayman’s SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody (Clone 048) can be used for immunohistochemistry (IHC) (paraffin).
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SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody
38102-50
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SLC3A2/CD98 Heavy Chain Rabbit Monoclonal Antibody
38102-50
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