Sheep Anti-Human Orexin A
Sheep anti Human orexin A antibody recognizes the human orexin A subunit of orexin, also known as hypocretin. Orexin is cleaved into Orexin A, also known as hypocretin-1, a 32 amino acid excitatory neuropeptide linked to alertness and wakefulness in humans. Orexin A binds to both orexin receptors 1 and 2 with similar affinity whilst orexin B corresponding to the C terminal region of the holopeptide binds only to the orexin receptor 2.Mutations in the orexin gene can lead to the development of Narcolepsy 1 (NRCLP1), a condition characterized by sleep fragmentation and daytime drowziness, abnormal REM sleep and sleep paralysis along with other sleep related symptoms (Peyron et al. 2000).Sheep anti Human orexin A antibody is a useful reagent for immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
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Sheep Anti-Human Orexin A
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