Sheep Anti-Human Erythropoietin receptor
Sheep anti Human erythropoietin receptor antibody recognizes the human Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function.Sheep anti Human erythropoietin receptor antibody (AHP1825) blocks Iodine125 labelled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies (Harris et al. 1992).Sheep anti Human erythropoietin receptor antibody is reported as suitable for use in immunocytochemistry and for use in functional studies. Removal of sodium azide is recommended prior to use in functional assays.
Do you have any questions about this product?
Order your product by email
Productname
Sheep Anti-Human Erythropoietin receptor
AHP1825
By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Request a sample
Productname
Sheep Anti-Human Erythropoietin receptor
AHP1825
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Are you looking for specific products, alternatives or documentation?
