Myeloid Tumor Gene Related 1 (MTGR1)
Myeloid tumor related gene (MTGR1) is found deleted in acute myeloidleukemia. Overexpression of MTGR1 can stimulate AML1-MTG8 to induce GCSF- dependent proliferation of L-G cells and to interfere with AML1-dependent transcription. AML1/MTG8 functions as a complex with MTGR1 andthat the complex might be important in promoting leukemogenesis.
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S130P
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