Rabbit Anti-Uracil DNA Glycosylase 1 (C Terminal)
Rabbit anti Uracil-DNA glycolase 1 antibody recognizes uracil-DNA glycosylase 1 (UNG1), a member of the uracil-DNA glycosylase and cyclin family. Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus.Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination.UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.
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Rabbit Anti-Uracil DNA Glycosylase 1 (C Terminal)
AHP1201
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Rabbit Anti-Uracil DNA Glycosylase 1 (C Terminal)
AHP1201
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