Rabbit anti Human heat shock protein 90 alpha antibody detects human heat shock protein 90 alpha (HSP90α), one of two HSP90 isoforms together with HSP90β. These isoforms are encoded by different genes and under normal conditions assist the folding of newly synthesised proteins, and are also important in cellular processes such as hormone signalling and cell cycle control. In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilised proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation. Induction of HSP90α by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.