PPARy Polyclonal Antibody

PPAR? is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{2160,6619,6620,4136} PPAR? mRNA is expressed prominently in adipose tissue, but is also found in large intestine, kidney, liver, and small intestine.{4980} Alternative splicing of the PPAR? gene results in at least two mRNA species that differ at their 5' ends.{2160,4540} Human PPAR?1 and PPAR?2 proteins are 53 and 57 kDa, respectively, based on the deduced amino acid sequences.{4540} PPAR?2 is the major PPAR? isoform found in both the cytosolic and nuclear fractions of undifferentiated 3T3-L1 cells.{7027} Total cellular PPAR?2 protein increases approximately 2-fold following differentiation of 3T3-L1 cells, whereas only small quantities of PPAR?1 are detected in the nuclear fraction following differentiation.{7027}