Paclitaxel octadecanedioate
Paclitaxel octadecanedioate is a prodrug form of paclitaxel (Item No. 10461) that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.{50209} Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 ?M. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner.
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