WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.{22296} For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.{20287} WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.{22296,24221} OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = Structural Genomics Consortium (SGC). The negative control, OICR-0547, for OICR-9429 is also available exclusively through the SGC. You can submit a request to receive the negative control here.