Mouse anti-E-CADHERIN, clone MX020 (Monoclonal)
ECAD (syn, CD325), 120 kDA, chromosome 16q22.1 (CDH1 gene), is a critical regulator of epithelial junction formation. It interacts with the cytoskeleton through several associated proteins. The ECAD internal domain binds with alpha, beta, gamma and p120 catenin’s to anchor the ECAD complex to the actin cytoskeleton of the cell. ECAD is expressed in virtually all epithelial cells except for adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells). Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer , pH6.0 for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Pancreas, lung adenocarcinoma, breast. Staining Membranous
Do you have any questions about this product?
Order your product by email
Productname
Mouse anti-E-CADHERIN, clone MX020 (Monoclonal)
MON10223
By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Request a sample
Productname
Mouse anti-E-CADHERIN, clone MX020 (Monoclonal)
MON10223
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Are you looking for specific products, alternatives or documentation?
