Melperone-d4 (hydrochloride)

Melperone-d4 is intended for use as an internal standard for the quantification of melperone (Item No. 19770) by GC- or LC-MS. Melperone is an atypical antipsychotic.{25511} It binds to ?1- and ?2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}