Mouse Anti-Pig CD27

Mouse anti Pig CD27 antibody, clone B30C7 recognizes the porcine homologue of human CD27, previously known as Swine Workshop Cluster 2 (SWC2), a T-cell co-stimulatory molecule belonging to the TNF receptor family. In humans the CD27 antigen is expressed by discrete populations of T- and B-cells where it functions in a co-stimulatory role to induce proliferation of T-cells and B-cells, however studies undertaken using the B30C7 clone have been unable to detect expression of CD27 on porcine B-cells (Reutner et al. 2012). Studies in humans have demonstrated CD27 to be involved in apoptosis, research in swine has shown that porcine CD27 is expressed by all naïve CD8a^-ve T-helper cells and a sub-population of CD8a^+ve cells (Reutner et al. 2012).Monoclonal antibodies to CD27 have previously been used to differentiate between subsets of NK cells and research utilizing clone B30C7 has shown that this monoclonal antibody may be used to differentiate between subsets of pig NK cells (Mair et al. 2013).