To be used in conjunction with Cayman’s lyso-PLD Polyclonal Antibody (Item No. 10005375) to block protein-antibody complex formation during immunochemical analysis of lyso-PLD. Lysophosphatidic acid (LPA) is an extracellular signaling lipid that evokes multiple biological functions including induction of platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and chemotaxis.{12477} Lyso-PLD was first discovered as the enzyme responsible for generating LPA from lysophosphatidylcholine (LPC).{13068} It was later revealed to be identical to an autocrine motility factor, autotaxin (ATX), which plays a role in tumor progression and metastasis.{13069,13071} Lyso-PLD/ATX mRNA is widely expressed with highest levels found in brain, ovary, lung, intestine, and testis.{13067,13070} Cayman’s lyso-PLD Polyclonal Antibody can be used for WB and ICC analysis for lyso-PLD on samples of human, murine, and rat origin. Other applications have not yet been tested.