L-erythro Sphingosine (d18:1)
L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1) (Item No. 10007907). It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%) and superoxide generation induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in neutrophils as well as reduces growth of CHO cells (IC50s = 1.3 and 2 ?M, respectively).{15200} L-erythro Sphingosine also inhibits dephosphorylation of the tumor suppressor retinoblastoma gene product (pRb; EC50 = 5 ?M) and growth of MOLT-4 acute lymphoblastic leukemia cells (IC50 = 3.7 ?M).{41482} [Matreya, LLC. Catalog No. 1826]
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