Interleukin-18 Rabbit Monoclonal Antibody

Interleukin-18 (IL-18) is a pro-inflammatory cytokine and member of the IL-1 cytokine family.{62956,62957} It is synthesized as an inactive precursor peptide, pro-IL-18, in macrophages, dendritic cells, Kupffer cells, keratinocytes, chondrocytes, synovial fibroblasts, and osteoblasts, where it is cleaved by inflammasome-activated caspase-1 to form active IL-18.{62956,62958} Active IL-18 is released from cells during pyroptosis, but inactive pro-IL-18 can also be secreted from dying cells and processed extracellularly by neutrophil proteinase 3, human chymase, and granzyme B.{62958} IL-18 binds to IL-18 receptors (IL-18Rs) on the surface of T helper 1 (Th1) and non-polarized T cells, natural killer (NK) cells, and NKT cells to induce intracellular signaling and IFN-? production in response to viral, bacterial, or parasitic infection.{62957,62958} It also binds to mast cells and basophils in conjunction with IL-3 to induce the production of IL-4 and IL-13, respectively. Inhibition of IL-18 with anti-IL-18 sera decreases survival in various mouse models of infection.{62958} Circulating levels of IL-18 are increased in patients with macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH).{62959} Cayman’s IL-18 Rabbit Monoclonal Antibody (Clone 011) can be used for ELISA and ELISA (CAP).