Interleukin-12R?2 (IL-12R?2) is a type I cytokine receptor that is involved in immunity.{67225} It is composed of an N-terminal immunoglobulin-like (Ig-like) domain, five fibronectin type III domains, which facilitate cytokine binding, a transmembrane domain, and an intracellular domain that contains tyrosine phosphorylation motifs. IL-12R?2 is selectively expressed in T helper 1 (Th1) over Th2 cells.{67226} IL-12R?2 forms a heterodimer with IL-12R?1 to form the IL-12R, and forms a homodimer or heterodimers with gp130 or IL-27R? to form receptors for IL-35, which all primarily act through the JAK/STAT pathway.{67227} It is the functional receptor for IL-12, as Th2 cells that express IL-12R?1 are unresponsive to IL-12 stimulation. Knockout of Il12rb2 (Il12rb2-/-) prevents increases in serum IFN-? levels in IL-12- or LPS-stimulated mice.{67228} Il12rb2-/- mice exhibit increased disease severity in a model of relapse-remitting experimental autoimmune encephalomyelitis.{67229} SNPs in IL12RB2 are associated with chronic obstructive pulmonary disease (COPD).{67230} Cayman’s Interleukin-12R?2 Rabbit Monoclonal Antibody (Clone 093) can be used for ELISA.