HumanKine recombinant human FGF-19 protein

FGF-19 is a member of the endocrine subfamily of FGFs. It primarily binds and activates signaling pathways downstream of FGFR4 in the liver. Through downregulation of the CYP7A1 enzyme, FGF-19 can prevent overproduction of bile salts in the liver and contribute towards their homeostasis. It is also a regulator of glucose and lipid metabolism alongside FGF-21. FGF-19 can additionally stimulate hepatocyte proliferation and has been correlated with the progression of hepatocellular carcinoma when its signaling levels are increased. (PMID: 30191047, 21437243, 20660733).