HumanKine recombinant human Cystatin C protein

Cystatin C is a 13-kDa protein that is expressed globally in the body. In healthy individuals, glomerular filtration in the kidney maintains it at a safe level. When kidney function is impaired, Cystatin C levels rise quickly. This makes it an early and sensitive biomarker of renal dysfunction (PMID 24848523). A mutation in Cystatin C has been associated with amyloid angiopathy (PMID 11409420). Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.