Product description Contact us for other availabe units

YKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.

Specifications
CAS number
2748220-93-9
Supplier
MedChem
Shipping & storage
Shipping condition
Room Temperature
Storage temperature
2-8°C

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YKL-5-124 TFA

HY-101257B-10mM

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YKL-5-124 TFA

HY-101257B-10mM

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