Glycine Receptor Polyclonal Antibody

Glycine is an important inhibitory transmitter in the brain stem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission.{14450} The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin.{14448} The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins.{14445,14449} These receptors have also been extremely useful in studies of synaptic clustering of receptors.{14447} The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor.{14446}