EP1 Receptor Polyclonal Antibody

The biological effects of PGE2 are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.{1422,6742} Binding of PGE2 to the EP1 receptor results in an increase in phosphatidyl inositol turnover with subsequent increase in intracellular free Ca2+.{3176,2034} Pharmacologically, EP1 receptors mediate contraction of smooth muscle.{1422} The human EP1 receptor is comprised of 402 amino acids with a molecular mass of approximately 42,000.{3176} The EP1 receptor is expressed in a variety of tissues, including the kidney, lung, and sensory neuron.{3176,2034,9050} Within the kidney, the EP1 receptor is expressed at high levels in the cortical, outer medullary, and inner medullary collecting duct.{2773}