Anti-DOK1

DOK1 contains pleckstrin homology domain and ten PXXP SH3 recognition motifs and is a critical substrate for p210 bcr/abl. DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors cells isolated from CML patients (1). DOK1 is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. Aberrant phosphorylation of DOK1 may contribute to the progression of different human diseases (2).