CXADR Rabbit Monoclonal Antibody

Coxsackievirus and adenovirus receptor (CXADR) is a type I transmembrane glycoprotein with roles in forming cellular tight junctions, spermatogenesis, and viral infection.{66291,66292} Alternative splicing of CXADR generates three soluble isoforms, CXADR4/7, CXADR3/7, and CXADR2/7, and two membrane-bound isoforms, CXADR1 and CXADR2.{66291} Membrane-bound isoforms of CXADR are composed of an extracellular domain containing two immunoglobulin-like (Ig-like) domains, a transmembrane domain, and an intracellular domain, which varies by isoform, is subject to post-translational modification, and contains a PDZ-binding motif, clathrin-adaptor protein recognition motif, and sorting motif. They function as major viral receptors for adenovirus species A and C-G and group B coxsackieviruses. Soluble isoforms of CXADR lack the transmembrane domain but also interact with both coxsackieviruses and adenoviruses. CXADR also functions as a cell junction component, interacting with various tight and adherens junction proteins to regulate barrier permeability, cell adhesion, and cell migration. Knockdown of CXADR in Sertoli cells compromises the blood-testis barrier, as well as induces germ cell apoptosis and premature loss of spermatids in mice.{66294} Endomyocardial CXADR expression is increased and positively correlated with IL-6 levels in patients with dilated cardiomyopathy.{66293} Cayman’s CXADR Rabbit Monoclonal Antibody (Clone 271) can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.