LFA-3/CD58 Rabbit Monoclonal Antibody

Lymphocyte function-associated antigen 3 (LFA-3), also known as CD58, is a membrane-associated glycoprotein.{65561} It exists as two isoforms: a type I transmembrane glycoprotein involved in signal transduction and a glycosylphosphatidylinositol-anchored (GPI-anchored) form primarily involved in cell adhesion.{65561,65562} A soluble form of LFA-3, sCD58, also exists.{65561} Transmembrane LFA-3 is composed of an N-terminal extracellular domain containing N-linked glycosylation sites, a transmembrane domain, and a short C-terminal cytoplasmic tail. The GPI-anchored form is located extracellularly and is linked to the plasma membrane via the C-terminus. LFA-3 is expressed broadly on hematopoietic and non-hematopoietic cells and its ligand, CD2, is expressed on T cells, natural killer (NK) cells, thymocytes, and certain bone marrow cells. LFA-3 acts as a co-stimulatory receptor that, when bound by CD2 on the surface of T cells, is part of the immunological synapse and induces T cell activation. It is also involved in thymocyte development and NK cell communication, as well as other immune and non-immune functions. sCD58 disrupts cell-cell adhesion and has immunosuppressive effects. Various SNPs in CD58 are associated with an increased risk of multiple sclerosis with one SNP potentially conferring a protective effect.{65563,65564} The expression of CD58 is increased or decreased in various cancers with increased expression positively correlated with overall survival and disease-free survival in patients with acute myeloid leukemia (AML).{65561} Cayman’s LFA-3/CD58 Rabbit Monoclonal Antibody (Clone 126) can be used for immunohistochemistry paraffin (IHC-P).