CB2 Receptor Polyclonal FITC Antibody

The central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors are G protein-coupled receptors (GPCRs) that bind the active component of cannabis, ?9-tetrahydrocannabinol, as well as anandamide which is an endogenous CB receptor ligand. This antibody has been raised against a sequence between the N-terminal and the first transmembrane domain of the protein of the human CB2 receptor.{6724} Conserved amino acids between the CB1 and CB2 receptors in this region are minimal.{6727} Human and mouse CB2 receptors exhibit 82% homology at the amino acid level over the complete protein.{6727} The CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells.{6724}