Carbofuran
Carbofuran is a carbamate insecticide that inhibits acetylcholinesterase (AChE) in insects and mammals (Kas = 9.4, 30, and 210 µM for M. domestica brain, A. mellifera brain, and bovine erythrocyte AChE, respectively).{36349} It also inhibits AChE from rat and human erythrocytes with IC50 values of 40 and 25 nM, respectively.{37694} It is toxic to the housefly M. domestica (LD50 = 4.6 mg/kg) and fourth-instar larvae of the mosquito C. pipiens with an LC50 value of 0.054 ppm. Carbofuran is toxic to birds, rats (LD50 = 4-11 mg/kg), and other mammals including dogs, sheep, and cattle, and is considered an environmental toxin.{36349,36347} Formulations containing carbofuran have been used in agriculture for the control of insects, nematodes, mites, and ticks.
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