Product description

IKKalpha is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex (1). IKKalpha is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure (2). IKKalpha is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFN alpha production. IKKalpha is also involved in the epidermis where it antagonizes mitogenic and angiogenic signals and represses tumor progression and metastases.

Specifications
Clonality
Polyclonal
Supplier
SignalChem
Shipping & storage
Shipping condition
Blue Ice
Storage temperature
2-8°C

Price on Request

Productname

Anti-IKK alpha

C51-63BR-100


Are you looking for specific products, alternatives or documentation?