CAMK2 alpha, Active

CAMK2? is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2? is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2? can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2? fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2? increased with heightened neuronal activity (2).