CAMK1, Active

CAMK1? or Ca2+/calmodulin-dependent kinase I-like kinase (CKLiK) is activated by Ca(2+) and calmodulin and is detected in CD34+-derived neutrophils and eosinophils, as well as in mature peripheral blood granulocytes (1). CAMK1? exhibits Ca(2+)/CaM-dependent activity that is enhanced in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha, consistent with detection of CAMK1D-activating activity in HeLa cells (2).