Anti-CD44, rabbit monoclonal - Optibodies

The CD44 antigen, also referred as homing cell adhesion molecule (HCAM), is a multi-structural and multifunctional cell-surface glycoprotein involved in cell–cell interactions, cell adhesion, and migration. Most tissues are CD44 positive, including astrocyte restricted precursor cells, breast myoepithelial cells, colon, lung type II pneumocytes, red blood cells, stomach, urothelial basal cells, uterus and white blood cells. Negative staining results is seen in testis, kidney tubular epithelium, cardiac muscle, hepatocytes. In disease, positive staining is seen in colorectal carcinoma (most), Langerhans histiocytosis, oligodendroglioma, thymoma, small cell prostate carcinoma.