Cytokeratin 14 (CK14) is an acidic type I human intermediate filament protein. It mostly found in basal cells of squamous epithelia, myoepithelium, some glandular epithelia and mesothelial cells. Molecular weight of CK14 is 50 kDa, and it usually pairs with CK5, which is a type II (basic) cytokeratin. In neoplastic cells, CK14 is a useful marker especially in identification of basal cell epithelium in prostate and myoepithelium in breast. It also useful for detecting squamous cell carcinomas. CK5 and CK14 antibodies can be used as a cocktail as well.