SLC6A2, also known as NET, is a
norepinephrine (noradrenaline) transporter, which regulates
norepinephrine homeostasis by reuptaking the
norepinephrine released into synaptic cleft in Na
+
- and Cl
-
-
dependent manner. Mutation of the SLC6A2 gene can
cause orthostatic intolerance, which is characterized by
lightheadedness, fatigue, altered mental condition, and
syncope. Drugs inhibiting the norepinephrine transporter
such as antidepressants, cocaine, and amphetamines also
lead to symptoms like orthostatic intolerance.