Selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively)1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors.
Productname
Dabrafenib
B08-901-05
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