Asialo Ganglioside GM2
Asialo ganglioside GM2 (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal ?-hexosaminidase A and B, respectively.{40891} It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients.{40892} This product contains asialo ganglioside GM2 molecular species with variable fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid. [Matreya, LLC. Catalog No. 1512]
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