Legenda image
Immunofluorescence: K562 cells stained withARG24092 anti-MAPK7 / ERK5 antibody.
Product description

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

Specifications
Applications
IP, IHC-Fr, WB, IF, ICC
Host
Rat
Clonality
Monoclonal
Clone
JAC6
Isotype
IgG1
Supplier
Arigo Biolaboratories Corporation
Shipping & storage
Storage temperature
-20°C

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anti-c-Myc antibody (JAC6)

ARG24107050

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anti-c-Myc antibody (JAC6)

ARG24107050

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