Legenda image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human epithelium and stromal cells in normal bowel mucosa tissue (4 µm sections) stained with ARG10554 anti-B Raf antibody [G11-G].
Product description

CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Specifications
Applications
IHC-P
Host
Rabbit
Clonality
Monoclonal
Clone
E19-G
Isotype
IgG
Supplier
Arigo Biolaboratories Corporation
Shipping & storage
Storage temperature
-20°C

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anti-CD45 antibody (E19-G)

ARG10558100

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anti-CD45 antibody (E19-G)

ARG10558100

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