anti-TNF alpha antibody (B1E4) (HRP)

Tumor Necrosis Factor alpha (TNF-?) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-? was named for its remarkable ability to cause hemorrhagic necrosis of tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-? regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-? functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-? not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-? hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-?, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-? therapy has been used for treatment of rheumatoid arthritis.