anti-MHC II DP mouse monoclonal, BraFB6, purified
MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an ? and ? chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. Positive control: Raji cells. Tonsil or lymph node.
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anti-MHC II DP mouse monoclonal, BraFB6, purified
691542
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anti-MHC II DP mouse monoclonal, BraFB6, purified
691542
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