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Anti-LIME1 Purified
11-410-C100
0,1 mg
€238
Product description
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
Specifications
Applications
IHC-P, WB
Host
Rabbit
Clonality
Polyclonal
Clone
PAb (410)
Isotype
Rabbit polyclonal
Supplier
Exbio
Product status
RUO
Shipping & storage
Storage temperature
2-8°C
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Anti-LIME1 Purified
11-410-C100
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Anti-LIME1 Purified
11-410-C100
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