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Anti-Hu CD180 Purified Low Endotoxin
12-637-C100
0,1 mg
€172
Product description
CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.
Specifications
Applications
FC, IP, FUNC
Host
Mouse
Clonality
Monoclonal
Clone
G28-8
Isotype
Mouse IgG1 kappa
Supplier
Exbio
Product status
RUO
Shipping & storage
Storage temperature
2-8°C
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Anti-Hu CD180 Purified Low Endotoxin
12-637-C100
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Anti-Hu CD180 Purified Low Endotoxin
12-637-C100
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