B-cell lymphoma/leukaemia-2 (Bcl-2) is an inhibitor of apoptosis, and its expression is generally abundant in cells which dividing and differentiating. In lymphatic tissue, Bcl-2 is highly expressed in T-cells, maturating B cells as well as mature B-cells. However, expression level in germinal center B-cells is downregulated. Overexpression of the Bcl-2 is common in leukemia and various carcinomas and sarcomas. Overexpression is common especially in non-Hodgkins lymphoma. Bcl-2 is helpful to classification of the follicular lymphoma or other lymphomas