Rabbit anti SKP2 antibody recognizes S-phase kinase-associated protein 2 (SKP2), also known as F-box protein Skp2, p45skp2 and Cyclin-A/CDK2-associated protein p45. SKP2 is a ubiquitin ligase, a critical component of the SKP2-SCF complex (
Nakayama and Nakayama 2005). It is frequently overexpressed in human cancer (
Chiarle et al. 2002). Loss of SKP2 can promote senescence in response to oncogene activation (
Lin et al. 2010). It plays a role in regulating cancer stem cell populations (
Chan et al. 2013).