Rabbit anti MCM2

Rabbit anti MCM2 antibody recognizes the nuclear protein mini chromosome maintenance protein 2 (MCM2), a putative DNA replicative helicase and member of the MCM family, critical during the initiation of DNA replication.During the G1 phase of the cell cycle the MCM proteins, part of the pre-replicative complex which assembles at replication origins, undergo phosphorylation by kinases including cyclin dependent kinase (CDK) and Cdc7/Dbf4 (DDK). Studies have shown that the phosphorylation of MCM2 occurs on multiple sites, namely Ser27, Ser41, Ser53, Ser108 and Ser139 and that phosphorylation results in a conformational change of the complex and activation of the helicase activity.