Rabbit Anti-Sigirr (C Terminal)

Rabbit anti SIGIRR (C-terminal) antibody recognizes the Single Ig IL-1-related receptor, also known as SIGIRR, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8 or TIR8. SIGIRR is a 409 amino acid ~ 45-90 kDa single pass type III transmembrane glycoprotein, Multiple species of SIGIRR seen in western blotting are achieved through differential glycosylation at four potential glycosylation sites in the SIGIRR ectodomain, mutation at these sites to eliminate glycosylation yields a single band of the predicted size (44 kDa) for unmodified SIGIRR (Zhao et al. 2015).SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily, defined by an intracellular Toll-IL-1R (TIR) domain. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signalling pathways. It interacts with TLR4, TLR5, TLR9 and IL-1R through the extracellular Ig domain, or the intracellular TIR domain. The Ig domain interferes with the heterodimerization of IL-1R while the intracellular TIR domain inhibits both IL-1 and LPS signalling by attenuating the recruitment of receptor-proximal signalling components to TLR4. SIGIRR is expressed in kidney, colon, small intestine, lung, spleen and liver. It is not expressed in brain or muscle.Rabbit anti SIGIRR antibody has been successfully used for the detection of SIGIRR in both murine and human samples by western blotting (Zhao et al. 2015)