Rabbit anti Human ORAI3 antibody recognizes the N-terminal region of human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca²⁺ entry through Ca²⁺ release-activated Ca²⁺ (CRAC) channels. CRAC channels are the main pathway for Ca²⁺ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca²⁺ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca²⁺ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.Rabbit anti Human ORAI3 antibody ( AHP1496) is not expected to cross react with either ORAI1 or ORAI2.