Rabbit Anti-BRCC36
Rabbit anti Human BRCC36 antibody recognizes human BRCA1/BRCA2 complex subunit 36 (BRCC36), a 36.7 kDa nuclear protein. BRCC36, together with BRCA1, BRCA2, Rad51 and BRCC45, forms a holoenzyme complex that possesses an ubiquitin E3 ligase activity.BRCC36 functions in enhancing cellular survival following DNA damage and that it is essential for ionizing radiation induced BRCA1 phosphorylation and nuclear foci formation and BRCC36 is aberrantly expressed in the majority of breast tumors indicating a potential role in the pathogenesis of the disease. BRCC36 could be a potentially important target in the treatment of radiation-resistant breast tumors (Chen et al. 2004).
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AHP1484
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