Rabbit anti Human SMAD3 antibody recognizes Mothers against decapentaplegic homolog 3 (SMAD3), a 50 kDa transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase, SMAD3 functions in cell proliferation, differentiation and development. Upon stimulation, SMAD3 oligomerizes with SMAD4 and translocates into the nucleus where it binds to DNA and transcription factors. SMAD3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.Defects in SMAD3 may be a cause of colorectal cancer (Sjöblom et al. 2006).
Productname
Rabbit Anti-SMAD3
AHP1465
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Productname
Rabbit Anti-SMAD3
AHP1465
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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