Anti-AOS1

AOS1 encodes a member of the SUMO-activating enzyme for the sumoylation of proteins that regulates protein structure and intracellular localization. AOS1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins. Sumoylation is a 2-step reaction in which the SUA1/UBA2 dimer functions as an E1 enzyme and UBC9 functions as an E2 enzyme (1). AOS1 is required for sumoylation of UBA2 by epitope-tagged sentrin-1, sentrin-2 and sentrin-3 (2).