Anti-phospho-ATF2 (Ser490 Ser498)

The activating transcription factor ATF2 (also called CRE-BP1) is a member of the ATF/CREB family of leucine zipper transcription factors, which binds both AP-1 and Cre DNA response element (1). ATF2 has two unique characteristics: it mediates adenovirus E1A-induced trans-activation and forms a heterodimer with c-Jun (2). ATF2 is a target of the JNK signal transduction pathway (3). ATF2 is phosphorylated by JNK on two closely spaced threonine residues located in the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. Furthermore, p38 MAPK can also phosphorylate ATF2.